49ers vs Broncos prediction
No 49ers vs Broncos game on today's card.
In short
This page carries every graded pick on 49ers vs Broncos this season and updates the next time they meet. Across 1 meeting this season, PicksToday.AI has graded 1 pick on 49ers vs Broncos, for +0.7 net units.
Form and injuries
49ers
2026 season
Record
6-1
No. 1 in the NFC West
Streak
L1
Home and away
Home 4-0 · Away 2-1
points per game
Scored28.1
Allowed19.9
Injuries
- Alfred Collins (DT) — Injured Reserve · Knee
- Demarcus Robinson (WR) — Injured Reserve · Ankle
- Isaac Guerendo (RB) — PUP · Pectoral
- Jake Tonges (TE) — Injured Reserve · Knee - MCL
- Kalia Davis (DT) — Injured Reserve · Quadriceps
- Nickolas Martin (LB) — Injured Reserve · Hamstring
- +10 more
Broncos
2026 season
Record
6-2
No. 1 in the AFC West
Streak
W4
Home and away
Home 4-0 · Away 2-2
points per game
Scored21.5
Allowed20.6
Injuries
- Caleb Lohner (TE) — Injured Reserve · Lower Body
- Damarri Mathis (CB) — Injured Reserve · Undisclosed
- Frank Crum (OT) — Injured Reserve · Undisclosed
- Jonah Elliss (LB) — Injured Reserve · Ankle
- Levelle Bailey (LB) — Injured Reserve · Leg
- Pat Bryant (WR) — Injured Reserve · Ankle
- +8 more
The model's NFL record
57
graded picks
57
decided
45.6%
win rate
-8.5
net units
-12.3%
ROI
| Market | Decided | Win % | Net | ROI |
|---|---|---|---|---|
| Moneyline | 57 | 45.6% | -8.5 | -12.3% |
Meetings this season
| Market | Pick | Price | Result | Units |
|---|---|---|---|---|
| October 4, 2026 | ||||
| Moneyline | San Francisco 49ers ML | -143 | WIN | 0.7u |
Keep reading
Both teams, the league, and how the numbers are kept.